ABSTRACT Objective To validate the content and usability of educational hypermedia about embracement and obstetric risk classification. Methods Methodological study, development by the basic instructional design model, conducted in five stages. Twenty-two judges participated to validate the content and usability. For the analysis, the Content Validity Index, the System Usability Scale, and the binomial test were used. Results In the content it was obtained a Content Validity Index of 0.96 and for and usability it was obtained 91.9. In the overall evaluation, all requirements obtained an index of 0.98. Conclusion The educational hypermedia developed presents evidence of validity and constitutes an innovative resource for the teaching and learning process in Nursing.

RESUMEN Objetivo Validar el contenido y la utilidad de la hipermedia educativa sobre el acolchado y la clasificación del riesgo obstétrico. Métodos Estudio metodológico, desarrollo del modelo de diseño instruccional básico, realizado en cinco etapas. Participaron 22 jueces para validar el contenido y la usabilidad. Para el análisis se utilizó el Índice de Validez de Contenido, la Escala de Usabilidad del Sistema y la prueba binomial. Resultados En el contenido se obtuvo un Índice de Validez de Contenido de 0,96 y para la usabilidad se obtuvo un 91,9. En la evaluación global, todos los requisitos obtuvieron un 0,98 de índice. Conclusión La hipermedia educativa desarrollada presenta evidencia de validez y se constituye como recurso innovador para el proceso de enseñanza y aprendizaje en Enfermería.

RESUMO Objetivo Validar o conteúdo e usabilidade de hipermídia educativa sobre acolhimento e classificação de risco obstétrico. Métodos Estudo metodológico, desenvolvimento pelo modelo de design instrucional básico, realizado em cinco etapas. Participaram 22 juízes para validar conteúdo e usabilidade. Para a análise, foram utilizados o Índice de Validade de Conteúdo a System Usability Scale e o teste binomial. Resultados No conteúdo obtiveram um Índice de Validade de Conteúdo de 0,96 e para e usabilidade obteve-se 91,9. Na avaliação global, todos os requisitos obtiveram 0,98 de índice. Conclusão: A hipermídia educativa desenvolvida apresenta evidência de validade e se constitui como recurso inovador para o processo de ensino e aprendizagem em Enfermagem.

SUMMARY Objetive: To monitor the light curing units available at undergraduate dental clinics of a Brazilian Public Higher Education Institution for seven uninterrupted years. Materials and methods: In the period between 2011-2017, the quality control of light curing units at the Faculty of Dentistry, Federal University of Goiás, was evaluated by analyzing their state of conservation and power density (mW/cm2). Data obtained were subjected to descriptive statistical analysis and Levene, Shapiro-Wilk, Kruskal-Wallis, Dunn and Chi-square tests (P <0.05). Results: Regarding the conservation status of the light curing units, comparatively, there was no statistically significant difference between the years 2012, 2016 and 2017 (p> 0.05). Statistically significant differences were found for power density values between years (p <0.0001). In pairwise comparisons, the power density values for the years 2011 (p <0.01) and 2012 (p <0.05) were statistically different from the years 2015, 2016 and 2017. Conclusions: A significant improvement in the state of conservation of light curing units was observed in the initial four years of evaluations, with a decline in the fifth year and stabilization in the last two years. Regarding the power density of the light curing units, a gradual increase was observed in the seven years of study, with stabilization of the results after the fifth year of quality control.

RESUMEN Objetivo: Realizar, durante siete años ininterrumpidos, un control y seguimiento de las fuentes de luz disponibles en las clínicas odontológicas de pre graado de una Institución de Enseñanza Superior Pública Brasileña. Material y métodos: Durante el período comprendido entre 2011-2017 se evaluó el control de calidad de las fuentes de luz de la Facultad de Odontología de la Universidad Federal de Goiás a través del análisis de su estado de conservación y de su densidad de potencia (mW/cm2). Los datos obtenidos se sometieron a un análisis estadístico descritpivo y a las pruebas de Levene, Shapiro-Wilk, Kruskal-Wallis, Dunn y Chi-cuadrado (P<0,05). Resultados: No se observaron diferencias estadísticas significativas del estado de conservación de las fuentes de luz entre los años 2012, 2016 y 2017 (p>0,05). Sí se observaron diferencias estadísticas significativas entre los valores de densidad de potência entre dichos años (p<0,0001). En las comparaciones por pares, los valores de densidad de potencia para los años 2011 (p<0,01) y 2012 (p<0,05) fueron estadísticamente diferentes de los años 2015, 2016 y 2017. Conclusiones: Comparativamente se observó una mejora sustancial del estado de conservación de las fuentes de luz en los cuatro años iniciales de evaluaciones, con una disminución en el quinto año y una estabilización en los dos últimos años. Durante los siete años de estudio de la densidad de potencia de las fuentes de luz se observó en un aumento gradual de la misma con una estabilización de los resultados a partir del quinto año de control de calidad.

ABSTRACT An important strategy for the sustainable management of Cerrado soils is no-till (NT) systems, which may improve soil properties, particularly aggregation. Soil aggregates can be categorized according to their formation pathways into physicogenic (Phy) and biogenic (Bio). This study aimed (i) to quantify the relative proportion of physicogenic and biogenic aggregates and (ii) evaluate the levels of total organic carbon and their respective humic and physical fractions in the aggregates’ formation pathways. The following managed and unmanaged sites were evaluated: a 6-year no-till site (6NT), an 18-year no-till site (18NT), a conventional tillage site (CT), and a reference Cerrado site (RS). Retained aggregates were analyzed morphologically, separated into Phy and Bio, and quantified. Subsequently, aggregates were subjected to total organic carbon (TOC) determination, fulvic acid carbon, humic acid carbon, humin carbon, particulate organic carbon (POC), mineral-associated organic carbon, and free light fraction carbon (FLFC). The proportion of Bio aggregates increased with decreasing management intensity. When TOC and humic acid carbon levels were compared between sites, it was found that Bio aggregates from 18NT and 6NT contained higher carbon content than Bio aggregates from CT. Particulate organic carbon and FLFC differed between aggregate types, with higher POC values observed in Bio aggregates from CT and 18NT and higher FLFC values in Bio aggregates from CT, 6NT, and 18NT. The practices adopted in the conservation management system favored biogenic aggregation in the Cerrado region, which can be proven through the study of the fractions of soil organic matter contained in these aggregates. The biogenic aggregation changed the SOM dynamics. Principal component analysis showed a clear distinction between conventional and conservationist management systems.

RESUMO Racional: Com o aumento do número de operações bariátricas torna-se maior o interesse pelo conhecimento, experiência e habilidades no manejo operatório e anestésico de obesos. A recuperação anestésica é ponto importante na abordagem terapêutica e menos efeitos adversos que retardem a alta são necessários estar em mente da equipe cirúrgica. Objetivo: Comparar técnicas anestésico-analgésicas na era poupadora de opioides através da administração epidural de anestésico local associado à morfina em baixa dose vs. à clonidina e analisar o impacto da analgesia na efetividade da recuperação pós-operatória comparando as duas técnicas. Métodos: Ensaio clínico randomizado e duplo-cego com 66 pacientes candidatos ao bypass gastrojejunal em Y-de-Roux divididos em dois grupos: grupo morfina e grupo clonidina. A analgesia multimodal incluiu na anestesia epidural com ropivacaína 0,375% 20 ml na altura da oitava vértebra torácica a associação de morfina (grupo morfina) em dose de 15 mcg/kg ou de clonidina (grupo clonidina) na dose 1 mcg/kg. Resultados: Os grupos se mostraram homogêneos e foi encontrada significância estatística ao analisar a diferença da dor entre eles no primeiro pós operatório. A dor foi superior no grupo clonidina, como também neste período o resgate analgésico foi melhor neste grupo. Nos demais tempos não houve significância nas diferenças quanto à dor e resgate. O retorno da motilidade intestinal no grupo morfina foi mais precoce no primeiro pós-operatório. Náuseas, vômitos e a alta hospitalar não apresentaram diferenças significativas entre os grupos. Conclusão: A anestesia epidural com morfina em baixa dose permitiu menor dor durante todo internamento com impacto positivo em relação a recuperação dos pacientes.

ABSTRACT Background: As the number of bariatric operations increases, there is a greater interest in knowledge, experience and skills in the operative and anesthetic management of obese people. Anesthetic recovery is an important point in the therapeutic approach and less adverse effects delaying discharge of these patients are necessary to be kept in mind by the surgical team. Aim: To compare anesthetic-analgesic techniques in the opioid-sparing era through epidural administration of local anesthetic associated with low-dose morphine vs. clonidine and analyze the impact of analgesia on the effectiveness of postoperative recovery by comparing these two techniques. Methods: Randomized, double-blind clinical trial with 66 patients candidates for Roux-en-Y gastrojejunal bypass divided into two groups: morphine group and clonidine group. Multimodal analgesia included epidural anesthesia with 0.375% ropivacaine 20 ml at the eighth thoracic vertebra with the association of morphine (morphine group) at a dose of 15 mcg / kg or clonidine (clonidine group) at a dose of 1 mcg / kg. Results: The groups were homogeneous and statistical significance was found when analyzing the difference in pain between them in the first postoperative period. The pain was higher in the clonidine group, as in this period, analgesic rescue was also better in this group. In the other times, there was no significance in the differences regarding pain and rescue. The return of intestinal motility in the morphine group was earlier in the first postoperative period. Nausea, vomiting and hospital discharge did not show significant differences between groups. Conclusion: Epidural anesthesia with low-dose morphine allowed less pain during the entire hospital stay, with a positive impact on patient recovery.

ABSTRACT Background: From the evidence, it is inferred the influence of cognitive or motivational variables over the emotional ones and from these on the perception and self-reported wellbeing and health, with direct implications for health promotion and prevention. Method: a quantitative approach, descriptive, correlational cross-sectional with statistical explanatory analysis investigation was conducted, analyzing the data through path modeling of the partial least squares approach of the structural equations model, by using the Smart PLS software 3.3.2 version, analyzing consequently the convergent and discriminant validity of the model. A total 223 undergraduate university young adult students was evaluated, 41 men (18,4%) and 182 women (81,6%) with ages between 18 and 30 years old (µ= 24,26 y σ=±3,30), from Bogotá Colombia participated. Results: The results allowed to significant relations between the self - determination with the impulsivity and emotional intelligence, and from these with the psychological well-being and healthy habits. There were not identified significant relations between the metacognition and the impulsivity, although there are between metacognition and emotional intelligence. Conclusions: The proposed model about the significant relations between metacognition and self-determination with impulsivity and emotional intelligence and between these and the psychological well-being and healthy habits was confirmed. The specific result related to the absence of significant relations between metacognition and the impulsivity suggest for futures research, to emphasize on the metacognitive process implicated on the emotional components. The results are discussed, its implications and the necessity to be considered more determinants for the promotion of health.

RESUMEN Introducción: A partir de la evidencia disponible, se infiere que variables cognitivas y motivacionales influyen sobre variables emocionales y estas a su vez influyen sobre la percepción y autorreporte de bienestar y salud, con implicaciones para la promoción y prevención. Método: Se realizó una investigación con enfoque cuantitativo, descriptiva, correlacional y con metodología de análisis explicativo, transversal, analizando los datos a través del modelado de ruta del enfoque de mínimos cuadrados parciales del modelo de ecuaciones estructurales, con el software Smart PLS versión 3.3.2., analizando consecuentemente la validez convergente y discriminante del modelo. Un total de 223 adultos jóvenes participaron, 41 hombres, (18,4%) y 182 mujeres (81,6%) con edades entre 18 a 30 años (µ= 24,26 y σ=±3,30) universitarios de pregrado o licenciatura, en Bogotá Colombia. Resultados: Se identificaron relaciones significativas entre la autodeterminación y la impulsividad e inteligencia emocional, y de estas a su vez con el bienestar psicológico y los hábitos saludables. No se identificaron relaciones significativas entre la metacognición y la impulsividad, aunque sí entre la metacognición y la inteligencia emocional. Conclusiones: Se confirma el modelo propuesto en el cual la metacognición y la autodeterminación se relacionan con la impulsividad y la inteligencia emocional y estas a su vez con el bienestar psicológico y los hábitos de vida saludable. Sobre la ausencia de relaciones entre la metacognición y la impulsividad se sugiere precisar a futuro sobre los procesos metacognitivos implicados que inciden en el control del componente emocional. Se discuten los resultados, sus implicaciones y la necesidad de considerar más determinantes simultáneamente, para la promoción de la salud.

RESUMO O estudo angiográfico intracraniano não invasivo está sendo amplamente utilizado no diagnóstico de doenças vasculares intracranianas. Com a crescente demanda e o aumento subsequente do uso dessa técnica na prática clínica, radiologistas e neurologistas devem estar cientes das opções nos parâmetros de imagem e como estes afetam a qualidade da imagem, as indicações clínicas, os métodos de avaliação e as limitações na interpretação dessas imagens. Devido ao aprimoramento das técnicas de imagem por RM, a possibilidade de avaliação precisa e direta das anormalidades na parede vascular arterial (vessel wall imaging) evoluiu, agregando dados substanciais ao diagnóstico quando comparados à avaliação indireta baseada em análises de fluxo convencionais. Neste artigo, os autores discorrem sobre a avaliação e interpretação dos achados de imagem desta nova técnica e suas aplicações clínicas.

ABSTRACT Intracranial vessel wall imaging plays an increasing role in diagnosing intracranial vascular diseases. With the growing demand and subsequent increased use of this technique in clinical practice, radiologists and neurologists should be aware of the choices in imaging parameters and how they affect image quality, clinical indications, methods of assessment, and limitations in the interpretation of these images. Due to the improvement of the MRI techniques, the possibility of accurate and direct evaluation of the abnormalities in the arterial vascular wall (vessel wall imaging) has evolved, adding substantial data to diagnosis when compared to the indirect evaluation based on conventional flow analyses. Herein, the authors proposed a comprehensive approach of this technique reinforcing appropriated clinical settings to better use intracranial vessel wall imaging.

Resumen El fenotipo es el efecto acumulativo del genotipo (G), del ambiente (A) y su interacción (G x A). El ambiente es el factor que afecta en mayor medida el fenotipo debido a que varía entre localidades, temporadas y estaciones del año, mientras que los efectos de los genotipos son constantes. El objetivo de este trabajo fue identificar genotipos de berenjena (Solanum melongena L.) altamente productivos y fenotípicamente estables, con frutos aceptables para los mercados de exportación y nacional, calificados, respectivamente, de primera y segunda categoría, a partir del análisis de estabilidad mediante el modelo AMMI y el índice de superioridad (Pi) de Lin y Binns. Para el efecto se utilizaron variables asociadas con rendimientos de 15 genotipos de berenjena evaluados en tres ambientes de la región Caribe de Colombia. Los resultados mostraron que: (1) El rendimiento de frutos de primera y segunda categoría fueron significativos (P < 0.001) para la interacción genotipo x ambiente, (2) los materiales C015, C027, C035, C036 y C049 lo fueron para el rendimiento de primera categoría y C014, C025, C032, C040 y C049 para el rendimiento de segunda categoría, ya que se ubicaron cerca al cero del CP1, por tanto contribuyen en menor medida a la interacción genotipo x ambiente y son los materiales con el comportamiento más estable; y (3) los genotipos más estables según el Pi para el rendimiento de primera categoría fueron el C006, C026, C027, C035 y C040; y para el de segunda categoría fueron C014, C035, C040, C042 y C049; los cuales, en su mayoría, coinciden con los genotipos más estables y de mayor rendimiento de acuerdo al análisis AMMI.

Abstract The phenotype is the cumulative effect of the genotype and the environment, and its interaction. As the environment is highly variable between locations and seasons, and the effects of genotypes are constant, the environment turns out to be the major factor affecting the phenotype. In view of the above, the objective of this work was to identify highly productive and phenotypically stable eggplant (Solanum melongena L.) genotypes, with fruits suitable for the export and national market, based on stability analysis using the AMMI model and the superiority index (Pi) of Lin and Binns in variables associated with yield in 15 genotypes of eggplant, in three environments of the Caribbean region of Colombia. The most relevant results were: (1) The yield of first and second category fruits were highly significant for the interaction genotype by environment; (2) the materials C015, C027, C035, C036 and C049 for the first category yields and C014, C025, C032, C040 and C049 for the second category yields, were located close to the zero of PC1, so they are considered the genotypes that less contribute genotype x environment interaction, and therefore are considered the genetic materials with the most stable behavior; and (3) the genotypes that appear as the most stable according to Pi for the first category yields were C006, C026, C027, C035 and C040, and second category yields were C014, C035, C040, C042 and C049; which, for the most part, coincide with the most stable and high-yielding genotypes according to the AMMI analysis.

Abstract Background: Argenteohyla siemersi (red-spotted Argentina frog) is a casque-headed tree frog species belonging to the Hylidae family. This species has a complex combination of anti-predator defense mechanisms that include a highly lethal skin secretion. However, biochemical composition and biological effects of this secretion have not yet been studied. Methods: The A. siemersi skin secretion samples were analyzed by mass spectrometry and chromatographic analysis (MALDI-TOF/MS, RP-HPLC and GC-MS). Proteins were also studied by SDS-PAGE. Among the biological activities evaluated, several enzymatic activities (hemolytic, phospholipase A2, clotting, proteolytic and amidolytic) were assessed. Furthermore, the cytotoxic activity (cytolysis and fluorescence staining) was evaluated on myoblasts of the C2C12 cell line. Results: The MALDI-TOF/MS analysis identified polypeptides and proteins in the aqueous solution of A. siemersi skin secretion. SDS-PAGE revealed the presence of proteins with molecular masses from 15 to 55 kDa. Steroids, but no alkaloids or peptides (less than 5 KDa), were detected using mass spectrometry. Skin secretion revealed the presence of lipids in methanolic extract, as analyzed by CG-MS. This secretion showed hemolytic and phospholipase A2 activities, but was devoid of amidolytic, proteolytic or clotting activities. Moreover, dose-dependent cytotoxicity in cultured C2C12 myoblasts of the skin secretion was demonstrated. Morphological analysis, quantification of lactate dehydrogenase release and fluorescence staining indicated that the cell death triggered by this secretion involved necrosis. Conclusions: Results presented herein evidence the biochemical composition and biological effects of A. siemersi skin secretion and contribute to the knowledge on the defense mechanisms of casque-headed frogs.

Abstract Anemia due to iron deficiency is the most common in the world being characterized as a significant public health issue. Therefore, its prevention and treatment are considered important before it becomes either chronic or grievous; the interventions with superior potential are the medical supplementation with iron salts as well as food mineral enhancement. The objectives of this study were to develop fermented dairy beverages supplemented with iron and added by Cerrado fruit pulps: cagaita (Eugenia dysenterica ), coquinho-azedo (Butia capitata), tamarindo (Tamarindus indica), and umbu ( Spondias tuberosa). In addition, the research intended to evaluate the acceptance of these beverages by children and adolescents from public schools in the city of Montes Claros (MG). The methodology consisted in the production of dairy beverages followed by the evaluation of their quality through physicochemical and microbiological analyses. Posteriorly, children and adolescents assessed the sensorial acceptance. The analyses performed presented satisfactory results for physicochemical and microbiological properties regarding the acceptance of the product. The cagaita and coquinho azedo based dairy beverages were the most accepted whether compared with tamarindo and umbu beverages. The fermented dairy beverage supplemented with iron and added by Cerrado fruits come up as a feasible alternative for dietary supplementation, and can promote beneficial effects in human health due to their sensorial acceptance.

RESUMO O protocolo com 30% da contração voluntária máxima do exercício isométrico com handgrip é amplamente utilizada para melhoria do sistema cardiovascular. Todavia, é desconhecido se a modulação da intensidade afetam essas respostas. Objetivou analisar as respostas cardiovasculares agudas após exercício isométrico com handgrip realizado em diferentes intensidades. Fizeram parte deste estudo cross-over 23 homens saudáveis. Os voluntários realizaram três sessões experimentais: 4x2 minutos de contração a 30% (S30) e 4x2 minutos de contração a 50% (S50) da contração voluntária máxima e controle (SC). A pressão arterial (PA) e os parâmetros da variabilidade da frequência cardíaca do domínio do tempo (SDNN, RMSSD e PNN50) e da frequência (LF, HF e LF/HF) foram obtidos antes e após as sessões. Nenhuma das sessões experimentais promoveram alterações estatisticamente significantes na PA sistólica e diastólica (p>0,05 para todos). Após a S50, houve menor aumento do SDNN nos cinco minutos pós-exercício (S50:+5±6; S30:+20±5;SC:+10±2 ms, p<0,05) e maior aumento do LF/HF após 20 minutos (S50:+1,59±0,80;S30:-0,49±0,49;SC:+0,39±0,49, p<0,05) comparado as demais sessões. Conclui-se que as respostas da PA ao exercício isométrico de handgrip são similares entre as intensidade, no entanto, o exercício mais intenso promoveu maior aumento da modulação simpática e redução da modulação parassimpática após exercício.

ABSTRACT The 30% maximal voluntary contraction protocol for isometric handgrip exercise is widely used to improve the cardiovascular system. However, it is unknown whether intensity modulation affects these responses. Objective: To analyze acute cardiovascular responses after isometric handgrip exercise performed at different intensities. Twenty-three healthy men participated in this cross-over study. The volunteers performed three experimental sessions: 4x2 minutes of contraction at 30% (S30) MVC and 4x2 minutes of contraction at 50% (S50) MVC, besides control (CS). Blood pressure (BP) as well as time (SDNN, RMSSD and PNN50) and frequency (LF, HF and LF/HF) domain heart rate variability parameters were obtained before and after sessions. None of the experimental sessions promoted statistically significant changes in systolic and diastolic BP (p> 0.05 for all). After S50, there was a smaller increase in SDNN five minutes after the exercise (S50: +5±6, S30: +20±5, SC: +10±2 ms, p <0.05) and higher LF/HF after 20 minutes (S50: +1.59±0.80, S30: -0.49±0.49, SC: +0.39±0.49, p <0.05) compared to the other sessions. In conclusion, BP responses to isometric handgrip exercise are similar between intensities; however, the most intense exercise promoted a greater increase in sympathetic modulation and decrease in parasympathetic modulation after exercise.

Introduction and objectives: Body shape (BSP) and body image (BI) are part of the external physical structure, then modifications in body shape necessarily affect body image; however, both combined have not been studied. The purpose of the study was to evaluate the statistical relationship between BSP and BI in university students. Method: Two hundred and ninety-six participants (17-35 years) were included in this study. Different anthropometric measurements were used to define their somatotype (BSP), body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC). In addition, a questionnaire on body image perception was applied (McElhone et al.), regarding "how do I look?", "how do I think others see me?", "how do others see me?", and "how do I want to look like?" Results: On average, men perceived themselves in normal weight; in contrast, women perceived themselves as overweight. Men were meso-endomorphic, while women were endo-mesomorphic as an average. Conclusion: Body shape measured as somatotype as well as WC and WHR were excellent determinants of body image. Participants who presented a higher endomorphy, WC and WHR and a lower ectomorphy had a higher appreciation of being overweight or obese and wish to become thinner.

Introducción y objetivos: la forma corporal (FC) y la imagen corporal (IC) son parte de la estructura física externa, por lo tanto, las modificaciones en la forma del cuerpo afectan necesariamente a la imagen corporal; sin embargo, combinados ambos no han sido estudiados. El objetivo del estudio fue evaluar la relación estadística entre FC e IC en estudiantes universitarios. Método: doscientos noventa y seis participantes (17-35 años) fueron incluidos en este estudio. Se utilizaron diferentes medidas antropométricas para definir el somatotipo, índice de masa corporal (IMC), índice cintura/cadera (ICC) y circunferencia de cintura (CC). Además, se aplicó un cuestionario sobre la percepción de la imagen corporal (McElhone et al.), relacionado con: "¿cómo me veo?", "¿cómo pienso que los demás me ven?", "¿cómo me ven los demás?" y "¿cómo quiero parecer? ". Resultados: en promedio, los hombres se perciben en peso normal; en cambio, las mujeres se perciben con sobrepeso. En promedio, los hombres fueron meso-endomórficos, mientras que las mujeres endo-mesomórficas. Conclusión: la forma corporal medida como somatotipo, ICC y CC fueron excelentes determinantes de la imagen corporal. Los participantes que presentaron mayor endomorfia, mayor ICC, mayor CC y menor ectomorfia tuvieron una mayor apreciación de sobrepeso u obesidad, y el deseo de verse más delgados.